Senior Associate (Clinical Track) Professor of Neurology

Phone: 404.727.5635

Penn State University, State College, PA B.S. 1987-90
University of Rochester School of Medicine and Dentistry, Rochester, NY M.D. 1990-98
University of Rochester School of Medicine and Dentistry, Department of Neurobiology and Anatomy, Rochester, NY M.S. 1992-94
University of Rochester School of Medicine and Dentistry, Department of Neurobiology and Anatomy, Rochester, NY Ph.D. 1992-96

1988 College of Science Freshman Recognition Award, Penn State University

1987-90 University Scholars Program, Penn State University

1987-90 Academic Excellence Scholarship, Penn State University

1990 Phi Beta Kappa

1990 College Marshall (Outstanding Student in Major), Penn State University

1990-98 Fellow, Medical Scientist Training Program, University of Rochester

1991 The Walle J. H. Nauta Neurosciences Award, University of Rochester

1992 Fellowship in Geriatric Pharmacology, Hartford Foundation/American Foundation for Aging Research (AFAR)

1992 Fellow, Pharmacological Sciences Training Program, University of Rochester (NIGMS T32 GM08427)

1993 Individual MD/PhD National Research Service Award, NIMH (F30 MH10512)

1997 Alpha Omega Alpha, University of Rochester

1998 The Robert J. Joynt Prize in Clinical Neurology, University of Rochester

2001 Javitts Junior Fellowship, sponsor Raymond Dingledine, PhD

2002-05 Fellow, Clinical Scientist Training Program, Emory University (T32 NS07480)

Foundation:

George C. Cotzias Memorial Fellowship, American Parkinson Disease Association
Title: Regulation of energy metabolism in midbrain dopamine neurons

Pending:

Mentored Clinical Scientist Development Award, NINDS, K08 NS048858
Title: Molecular mechanism of selective neuronal vulnerability

Research Focus:

My laboratory focus is on mechanisms of selective neuronal vulnerability in neurodegenerative diseases. Using global assessment of gene expression, live-cell imaging, and assays of cellular metabolism and toxicity, we are attempting to determine pathogenic mechanisms of dopamine neuron death in Parkinson's disease.

Publications

Collier TJ, Greene JG, Felten DL, Stevens SY, and Collier KS (2004) Reduced cortical noradrenergic neurotransmission is associated with increased neophobia and impaired spatial memory in aged rats. Neurobiol Aging 25: 209-221.

Greene JG, Dingledine R, and Greenamyre JT (2005) Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism. Neurobiol Dis 18(1): 19-31 (Epub 11/11/20004).

Book Chapters:

Greene JG and Greenamyre JT (2004) Mitochondria, metabolic inhibitors, and neurodegeneration. In: Neurodegenerative Diseases: Neurobiology, Pathogenesis, and Therapeutics, MF Beal, ed, Cambridge Press, London.

Greene JG and Greenamyre JT (2005) Excitotoxicity in Parkinson’s disease. In: Parkinson’s Disease, M Ebadi and R Pfeiffer, eds., CRC Press, Boca Raton.

Other Publications:

Greene JG, Greenamyre JT, and Dingledine R (2004) Gene expression profile of chronic complex I inhibition in an in vitro model of Parkinson’s disease. Society for Neuroscience Abstracts.

Borges K, Shaw R, Greene JG, and Dingledine R (2004) Microarray analysis of three hippocampal cell populations before and after seizure preconditioning. Society for Neuroscience Abstracts.

Greene JG, Finch EA, Greenamyre JT, and Dingledine R (2005) Comparison of intracellular calcium and mitochondrial membrane potential responses between dopaminergic and nondopaminergic neurons in primary cultures from mouse ventral mesencephalon. Society for Neuroscience Abstracts.(submitted).