1983, Cornell University, B.S., Neurobiology, Ithaca, New York
1987, The Johns Hopkins University M.D., School of Medicine, Baltimore, Maryland
Grant Support
Active Support
Grant Title:Functional status of 5HT in aging & late-life depression
Funding Agency: NIH R01 MH59945
Dates:August 2000 – July 2005
Grant Title:Age/sex effects on the central serotonin system
Funding Agency: NIH R01
Dates:May 5, 2004 – March 31, 2008
Grant Title:Imaging the depression/dementia interface
Funding Agency:NIH K24 MH64625
Dates:January 2003 – December 2007
Grant Title:Alzheimer’s Disease Research Center
Funding Agency: NIH P01
Dates:April 2000 – March 2010
Grant Title:Psychobiology of suicidal behavior in BPD
Funding Agency:NIH R01 MH48463
Dates:June 2001 – May 2006
Grant Title:In Vivo PIB PET Amyloid Imaging: Normals, MCI & Dementia
Funding Agency:NIA P01 AG025204
Role: Consultant (PI: Steven T. DeKosky)
Dates:May 15, 2005 – April 30, 2010
Grant Title:Development of [F-18]-labeled amyloid imaging agents for PET
Funding Agency:Department of Energy DE-FG02-03ER63590
Role:Co-Investigator
Dates:December 15, 2003 – December 14, 2006
Grant Title:Neurobiology of feeding and other behavior in bulimia
Funding Agency:NIH R01 MH42984
Role:Co-Investigator
Dates:March 1, 2004 – February 28, 2007
Grant Title:Serotonin - A trait disturbance in anorexia nervosa?
Funding Agency:NIH R01 MH0600111
Role:Co-Investigator
Dates: April 1, 2004 – March 31, 2007
Grant Title:Simple in vivo PET measure of amyloid binding in AD
Funding Agency: NIH R01 MH070729
Role:Co-Investigator
Dates:May 13, 2004 – August 30, 2007
Grant Title:PET imaging of post-partum depression
Funding Agency:NIH K07
Role:Co-Mentor (PI: Eydie Moses-Kolko)
Dates:September 2002 – August 2007
Grant Title:Neurobiology of neurodegenerative disorders
Funding Agency:NIMH training grant, T32 NS07391
Role:Training faculty (PI: Michael Zigmond)
Dates:July 2002 – June 2007
Grant Title:Cardiovascular Behavioral Medicine Training Grant
Funding Agency:NIH
Role:Training faculty (PI: Karen Matthews)
Dates:July 2003 – June 2008
Grant Title: Monocytes in HIV encephalitis
Funding Agency:NIH R01 MH64921
Role:Consultant (PI: Clayton A. Wiley)
Dates:April 2002 – March 2007
Grant Title:Neuroimaging medical illness in elderly depression
Funding Agency:NIH K01 MH01976
Role:Consultant (PI: Julie C. Price)
Dates:April 2001 – March 2006
Grant Title:PET tracers to monitor vaccine and immune therapy for AD
Funding Agency:NIH R01 AG20226
RoleCollaborator (PI: William Klunk)
Dates:September 2001 – July 2006
Grant Title:Predictors of treatment response in late-life depression
Funding Agency:NIH K23 MH064678
Role:Consultant (PI: Howard Aizenstein)
Dates:January 1, 2002 – December 31, 2006
Grant Title:Primary insomnia: psychobiology and treatment response
Funding Agency:NIH R01 MH24652
Role:Consultant (PI: Daniel Buysse)
Dates:December 2001 – November 2006
Grant Title:PET imaging with serotonin ligands in eating disorders
Funding Agency:NIH K05 ER63590
Role:Consultant (PI: Walter Kaye)
Dates:February 2001 –January 2006
Grant Title:Geriatric Depression: Getting Well, Staying Well (SWELL)
Funding Agency:NIH R01
Role:Consultant (PI: Charles F. Reynolds, III)
Dates:June 2004 – April 2009
Grant Title:Maintenance therapies of late-life depression-III
Funding Agency:NIH R01 MH43832
Role:Consultant (PI: Charles F. Reynolds, III)
Dates:March 1, 2004 – February 28, 2009
Grant Title:PET imaging probes for amyloid in Alzheimer's and aging
Funding Agency:NIH K02 AG01039
Role:Collaborator (PI: William Klunk)
Dates:July 2001 – January 2006
Grant Title:WHIMS-MRI: Effects of hormone therapy on subclinical neurological pathology
Funding Agency:NIH
Role:Consultant (PI: Lewis Kuller)
Dates:
Grant Title:Cognition in Euthymic Older Adults with Bipolar Disorder
Funding Agency:NIH K23
Role: Consultant (PI: Ariel Gildengers)
Dates:April 20, 2005 – March 31, 2010
Grant Title:Pharmacodynamics of IV citalopram using functional MRI
Funding Agency:NIH F32
Role: Consultant (PI: Kristin Bigos)
Dates:July 31, 2005 - July 30, 2007
Grant Title:Amyloid pathology and cognition in normal elderly
Funding Agency:NIH R01
Role:Consultant (PI: William Klunk)
Dates:March 1, 2005 – February 28, 2010
Grant Title:FMRI in the examination of episodic memory after brain injury
Funding Agency:NIH R01
Role:Consultant (PI: Joseph H. Ricker)
Dates:July 15, 2005 – May 31, 2009
Grant Title:Training biostatisticians in psychiatric research
Funding Agency:NIH T32
Role: Teaching Faculty (PI: Sati Mazumdar)
Dates:August 1, 2005 – July 31, 2010
Grant Title:Pathways linking late-life depression to mild cognitive impairment and dementia
Funding Agency:NIH R01
Role: Consultant (PI: Meryl Butters)
Dates:July 1, 2005 – June 30, 2010
Grant Title:In vivo imaging of serotonin transporter in the aging brain
Funding Agency:Competitive Medical Research Fund (University of Pittsburgh)
Role:Co-Investigator (PI: Joan Lakoski)
Dates:April 2005 – March 2006
Grant Title:Center of Excellence for the Detection, Diagnosis and Intervention of Dementia
Funding Agency:State of Pennsylvania Tobacco Settlement Fund
Role:Co-investigator/Project PI, 2% effort (PI: Steven T. DeKosky)
Dates:June 2005 – May 2009
Publications
Published and Accepted Articles in Referred Journals
Zimmer LA, Snyderman C, Fukui MB, Bascom D, Blodgett T, McCook B, Townsend DW, Meltzer CC. The use of combined PET/CT for localizing recurrent head and neck cancer: the Pittsburgh experience. ENT-Ear Nose and Throat Journal 2005;84(2):104-110.
Nofzinger EA, Buysee, DJ, Germain A, Price J, Meltzer CC, Miewald JM, Kupfer DJ. Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression. Archives of General Psychiatry 2005;62(4):387-396.
Jennings JR, Muldoon MF, Ryan C, Price JC, Greer P, Sutton-Tyrell K, van der Veen FM, Meltzer CC. Reduced cerebral blood flow response and compensation among non-medicated hypertensives. Neurology 2005;64:1358-1365.
Branstetter BF, Blodgett TM, Zimmer LA, Snyderman CH, Johnson JT, Raman S, Meltzer CC. Depiction of head and neck malignancy: Is PET/CT more accurate than PET or CT alone? Radiology2005; 235(2):580-586.
Blodgett TM, Fukui MB, Snyderman CH, Branstetter BF, McCook BM, Townsend DW, Meltzer CC. Combined PET-CT in the head and neck. Part 1. Physiologic, altered physiologic, and artifactual FDG uptake. Radiographics 2005;25:897-912
Fukui MB, Blodgett TM, Snyderman CH, Johnson JJ, Myers EN, Townsend DW, Meltzer CC. Combined PET-CT in the head and neck. Part 2. Diagnostic uses and pitfalls of oncologic imaging. Radiographics 2005;25:913-930
Kaye WH, Frank GK, Bailer UF, Henry SE, Meltzer CC, Price JC, Mathis CA, Wagner A. Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies. Physiology and Behavior 2005;85(1):73-81.
Soloff PH, Meltzer CC, Becker C, Greer PJ, Constantine D. Gender differences in a fenfluramine-activated FDG PET study of Borderline Personality Disorder. Psychiatry Research: Neuroimaging 2005;138(3):183-195.
Bohnen NI, Kaufer DI, Hendrickson R, Ivanco LS, Lopresti B, Koeppe RA, Meltzer CC, Constantine G, Davis JG, Mathis CA, DeKosky ST, Moore RY. Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease. Journal ofNeurology, Neurosurgery & Psychiatry 2005;76(3):315-319.
Bailer UF, Frank GK, Henry SE, Price JC, Meltzer CC, Weissfeld L, Mathis CA, Drevets WC, Wagner A, Hoge J, Ziolko S, McConaha CW, Kaye WH. Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]WAY100635. Archives of General Psychiatry 2005;62:1032-1041.
Bell-McGinty S, Lopez OL, Meltzer CC, Scanlon JM, Whyte EM, DeKosky ST, Becker JT. Differential cortical atrophy in subgroups of mild cognitive impairment. Archives of Neurology2005;62(9):1393-1397.
Nebes RD, Pollock BG, Meltzer CC, Saxton JA, Houck PR, Halligan EM, DeKosky ST. Serum anticholinergic activity, white matter hyperintensities and cognitive performance. Neurology 2005;65:1487-1489.
Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. Journal of Cerebral Blood Flow and Metabolism 2005;l25:1528-1547.
Kondziolka D, Steinberg GK, Wechsler L, Meltzer CC, Elder E, Gebel J, DeCesare S, Jovin T, Zafonte R, Lebowitz J, Flickinger JC, Tong D, Marks MP, Jemieson C, Luu D, Bell-Stephens T, Teraoka J. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. Journal of Neurosurgery 2005;103:38-45.
Frank GK, Bailer UF, Henry SE, Drevets W, Meltzer CC, Price JC, Mathis CA, Wagner A, Hoge J, Ziolko S, Barbarich-Marsteller N, Weissfeld L, Kaye WH. Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C]raclopride. Biological Psychiatry 2005;58(11):908-12.
Lopresti BJ, Klunk WE, Mathis CA, Hoge JA, Ziolko SK, Lu X, Meltzer CC, Schimmel K, Tsopelas N, DeKosky ST, Price JC. Simplified quantification of Pittsburgh Compound-B amyloid imaging PET studies: a comparative analysis. Journal of Nuclear Medicine 2005;12(6):1959:1972.
*Carmichael O, Aizenstein HJ, Davis SW, Becker JT, Thompson PM, Meltzer CC, Liu Y. Atlas-based hippocampus segmentation in Alzheimer’s disease and mild cognitive impairment. Neuroimage 2005;27:979-90.
*Lee M, Bailer UF, Frank GK, Meltzer CC, Price JC, Mathis CA, Ferrell RE, Devlin B, Kaye WH. Relationship of a 5-HT transporter functional polymorphism to 5-HT1A receptor binding in healthy women. Molecular Psychiatry 2005;10(8):715-716.
Jennings JR, van der Veen FM, Meltzer CC. Verbal and spatial working memory in older individuals: a positron emission tomography study. Brain Research 2006;1092:177-189.
Becker JT, Davis SW, Hayashi KM, Meltzer CC, Toga AW, Lopez OL, Thompson PM. Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment. Archives of Neurology 2006;63:97-101.
Wiley CA, Lopresti BJ, Becker JT, Boada F, Lopez OL, Mellors J, Meltzer CC, Wisniewski SR, Mathis CA. PET imaging of peripheral benzodiazepine receptor binding in infected subjects with and without cognitive impairment. Journal of Neurovirology 2006;12(4):262:271.
Book Chapters
Meltzer CC, Boada F, Pettegrew JW, Scanlon JM. Imaging Neurobehavioral Disorders. In: RE Latchaw, J Kucharczyk, ME Mosley, eds. Advanced Imaging and Image-Guided Therapy of the Nervous System. Elsevier Mosby, Philadelphia, 2005, pp. 1161-1186.
Smirniotopoulos JG, Meltzer CC. Primary Intra-axial Neoplasms. In: RE Latchaw, J Kucharczyk, ME Mosley, eds. Advanced Imaging and Image-Guided Therapy of the Nervous System. Elsevier Mosby, Philadelphia, 2005, pp. 745-770.
Thomas S, Fukui MB, Seth R, Meltzer CC. Correlative Imaging in Neurology and Neurosurgery. In: Henkin et al., eds. Nuclear Medicine, 2nd edition, (in press).
Branstetter BF, Blodgett TM, Meltzer CC. PET/CT of Head and Neck Cancers. In: Shreve et al., eds. Clinical PET-CT, Springer, (in press).