Laval University, Quebec, Canada MSc 1985 Neurobiology
Laval University, Quebec, Canada PhD 1988 Neurobiology
1996-2002 Associate Professor, Yerkes Regional Primate Research Center and Dept of Neurology, Emory Univ.
1991-1996 Assistant Professor, Dept. Anatomy, Fac. Medicine, Laval Univ., Québec, Canada
1991-1991 Postdoctoral Fellow, Dept. Neurology, Emory Univ., Atlanta, GA, Supervisor: Dr. Mahlon DeLong
1990-1991 Postdoctoral Fellow, Dept. Neurology, Johns Hopkins Univ., Baltimore. Supervisor: Dr. Mahlon DeLong
1988-1990 Postdoctoral Fellow, MRC Unit, Dept. Pharmacology, Oxford Univ., UK. Supervisor: Dr. J. Paul Bolam
1996-1999 Scholarship from the Fonds de la Recherche en Santé du Québec
1991-1996 Scholarship from the Medical Research Council of Canada
R01 NS037423-06A1 Smith (PI) 09/01/2003-08/30/2007
NIH/NINDS
Metabotropic Glutamate Receptors in the Basal Ganglia
The goal of this project is to characterize the subcellular and subsynaptic localization of Homer proteins in the primate basal ganglia and study their role in trafficking of metabotropic glutamate receptors.
Role: PI
R01 NS42937-01 Smith (PI) 07/01/2002-06/30/2006
NIH/NINDS
"GABA-B Receptors and Parkinson's disease"
This project aims at characterizing the localization and role of GABA-B receptors in the pre-synaptic modulation of glutamate release in primate basal ganglia. We also propose to test GABA-B agonists as potential therapeutic agents in parkinsonian monkeys.
2R01 NS 37948-05 Smith (PI) 05/01/2002-04/30/2006
NIH/NINDS
GABA Receptors in Thalamus
This project aims at characterizing the subcellular and subsynaptic localization of GABA-A and GABA-B receptors in the ventral motor and intralaminar nuclei of the thalamus in normal and parkinsonian monkeys
Research Grant (#98228051) Smith (PI) 07/01/1999-06/30/2005 (No-cost extension)
U.S. Army Medical Research and Material Command (USMRMC)
Kainate Receptors in the Striatum: Implications for Excitotoxicity in Huntington‚s Disease
This project aims at characterizing the source, synaptic organization and subsynaptic localization of pre-synaptic kainate receptor subunits in the monkey striatum.
R01 NS048334 Conn (PI) 12/01/2004-11/30/2006
NIH/NINDS
Metabotropic Glutamate Receptors in Basal Ganglia
This project aims at elucidating the roles of group III mGluRs in regulating inhibitory synaptic transmission in basal ganglia output nuclei.
DA 10732-01 Kuhar (PI) 05/01/2001-04/30/2006
NIH/NIDA
CART: A novel cocaine regulated neurochemical
This project aims at characterizing the localization and functions of CART peptides in the rat brain
R01 NS049474-01 Wichmann (PI) 07/2001/05-06/30/2009
NIH/NINDS
Functions of Dopamine in the Sustantia Nigra
The goal of this project is to elucidate the localization and functions of D1 and D2 receptors in regulating neurotransmission in the substantia nigra of normal and parkinsonian monkeys.
Most Recently Completed Research Support
P50 NS38399 DeLong (PI) 12/01/1998-11/30/2004
NIH/NINDS
Models of Parkinson's Disease: Therapeutic Implications
The goal of this project is to elucidate the localization and functions of pre-synaptic metabotropic glutamate receptors associated with afferents to basal ganglia output structures in rats.
R01 NS37948 Smith (PI) 04/01/1998-03/31/2002
NIH/NINDS
"Synaptic Inputs to Thalamostriatal Neurons"
This projects aims at elucidating the synaptic inputs to thalamostriatal neurons in the centromedian/parafascicular nuclei in monkeys.
R01 NS37423-01 Smith (PI) 05/01/1998-04/30/2004
NIH/NINDS
"Glutamate and GABA-A Receptors in the Basal Ganglia"
The goal of this project is to elucidate various aspects of the subsynaptic localization of metabotropic glutamate receptors and GABA-A receptor subunits in the primate basal ganglia in normal and pathological conditions.
Parkinson Disease Foundation Grant (No grant number) Smith (PI) 07/01/00-06/30/01
PDF
GABA-B Receptors in Parkinson's Disease
The goal of this project is to elucidate the subsynaptic localization of GABA-B receptors in the basal ganglia and test the potential therapeutic benefits of GABA-B agonists in parkinsonian monkeys.
2003-2004: Director of Graduate Studies, Graduate Neuroscience Program, Emory University
2003-present: Section Editor for Neuroscience (Neuropharmacology)
2000-present: Member of editorial Board of Neuroscience, J. Chemical Neuroanatomy, Synapse
2002-present: Member of Merit Review Grants Sub-committee for Neurobiology-Dept Veteran Affairs
2001-present: Treasurer International Basal Ganglia Society
1998-present Ad Hoc reviewer for grant applications to NINDS, Welcome Trust and MRC, UK; Hong Kong MRC
1996-present Ad Hoc reviewer for peer-reviewed manuscripts submitted to J. Neuroscience, J. Comp. Neurol., Brain Research, J. Histochem. Cytochem.
1991-present Memberships for: International Basal Ganglia Society; International Brain Research Organization; Society for Neuroscience
Publications
Kuwajima, M, MH Dehoff, SC Collins, RA Hall, PF Woerley and Y Smith (2004) Homer proteins regulate the subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the mouse pallido-subthalamic complex . Society for NS, abstr. 162.4
Paquet, M, AM Castleberry, M Kuwajima, S Fam, CC Yun, Y Smith, RA Hall (2004) Metabotropic glutamate receptors interact with the scaffold protein NHERF-2. Society for NS abstr. 162.19.
Pare, J,Y Smith (2004) Acetylcholine co-localizes with GABA or glutamate in ascending brainstem inputs to the substantia nigra/ventral tegmental area and subthalamic nucleus in monkey. Soc for NS abstr 307.1
Raju, DV, J Pare and Y Smith (2004) A subset of cholinergic terminals co-express the vesicular glutamate transporter 1 in the monkey striatum. Soc for NS abstr 307.2
Mitrano, DA and Y Smith (2004) Localization of mGluR1a in the shell and core of the nucleus accumbens: A comparative analysis between monkeys and rats. Soc for NS abstr 393.4
Philpot, KB, S Dall Vechia Adams, Y Smith and MJ Kuhar (2004) The food connection: characterization of the synaptic connectivity of CART-immunoreactive neurons in the lateral hypothalamus/perifornical area in the rat. Soc for NS abstr 544.11
Bordelon, JR, Y Smith, LL Howell, P Greengard and EC Muly (2004) Differential localization of protein phosphatase-1 (PP1) isoforms at axospinous synapses: Response to haloperidol and cocaine treatment. Soc for NS abstr 632.8
Raju, DV and Y. Smith (2004) Differential subcellular distribution of vesicular glutamate transporters 1 and 2 in the rat striatum. 8th IBAGS meeting, Crieff, P34.
Smith, Y and J-F Pare (2004) Differential co-localization of GABA and glutamate in ascending brainstem cholinergic inputs tobasal ganglia in monkeys. 8th IBAGS meeting, Crieff, P45
Smith, Y, S. Haber, L. Kerkerian-LeGoff and I. Stanford (2004) The known, unknown and intriguing features of the thalamostriatal system. 8th Ibags meeting, Crieff, S29.
Villalba, R and Y. Smith (2004) Comparative ultrastructural analysis of GABA-A and GABA-B receptors in basal ganglia-receiving thalamic nuclei in monkeys. 8th IBAGS meeting, Crieff, P86.
Kuwajima, M., M. Dehoff, SC Collins, PF Woerley and Y. Smith (2004) Homer proteins regulate the subcellular localization of group I metabotropic glutamate receptors in the mouse globus pallidus: A comparative study with the subthalamic nucleus. 8th IBAGS meeting, Crieff, P87.
Galvan, A., Y. Smith and T. Wichmann (2004) GABAergic transmission in the monkey globus pallidus: An in vivo study using extracellular recording and intracerebral drug infusion. 8th IBAGS meeting, Crieff, P76.
Poisik, OV, A. Rodriguez, M. Verreault, PJ Conn and Y. Smith (2004) Metabotropic glutamate receptor 2 regulates excitatory synaptic transmission in the rat globus pallidus. 8th IBAGS meeting, Crieff, P65.
Jin, XT, and Y. Smith (2004) Pre- and post-synaptic effects of kainate receptors on excitatory synaptic transmission in the rat globus pallidus. 8th IBAGS meeting, Crieff, P 66.
Pare, J-F, DV Raju and Y. Smith (2005) Axonal tract tracing: A historical survey of neuroanatomical tract tracing methods. Soc for Neurosci abstr 18.19
Raju, DV, D. Lynn and Y. Smith (2005) Understanding neurological disease through neuroanatomy: A teaching module for first year undergraduate students. Soc for Neurosci. Abstr 20.9
Raju DV, DJ Shah, M Verreault, Y Smith (2005) Synaptology of thalamostriatal afferents from intralaminar and relay nuclei in rat. Soc for Neurosci. abstr 180.1
Pare J, DV Raju, TH Ahern and Y Smith (2005) Changes in subcellular distribution of vesicular glutamate transporter 1 in the MPTP monkey model of Parkinson’s disease. Soc for Neurosci abstr 180.2
Smith Y., DV Raju, TH Ahern and M Verreault (2005) Striatal and cortical projections of the dorsal and ventral tier thalamic relay nuclei in rat. Soc for Neurosci abstr 180.9
Borges, K, H Irier, Y Smith and R Dingledine (2005) Degeneration and repopulation of astrocytes in dentate gyrus after pilocarpine-induced status epilepticus. Soc for Neurosci Abstr 217.14
Poisik, OV, PJ Conn and Y Smith (2005) Dopamine modulates the functions of the group I metabotropic glutamate receptors in the rat globus pallidus. Soc for Neurosci Abstr. 263.12
Kuwajima, M, RA Hall and Y Smith (2005) Expression of group I metabotropic glutamate receptors in the pallido-subthalamic complex in the MPTP-mouse model of Parkinson’s disease. Soc for Neurosci abstr 331.8
Jin, X and Y Smith (2005) Presynaptic kainate receptor modulates GABAergic and glutamatergic transmission in the rat globus pallidus. Soc for Neurosci Abstr 631.8
Villalba, RM and Y Smith (2005) Subsynaptic localization of GABA-B receptors at glutamatergic synapses in the monkey thalamus. Soc for Neurosci abstr 959.2
Mitrano DA and Y Smith (2005) Subsynaptic localization of group I mGluRs in the nucleus accumbens of normal and cocaine-treated rats. 5th International mGluRs meeting, Taormina, abstr 85
Jones CK, MJ Marino, Y Nong, O Valenti, GG Kinney, O Poisik, L Williams, Y Smith and PJ Conn (2005) Modulation of the basal ganglia by metabotropic glutamate receptors: potential novel approaches for the treatment of Parkinson’s disease. 5th International mGluRs meting, Taormina, abstr 65.
Poisik, OV, PJ Conn and Y Smith (2005) Modulation of group I metabotropic glutamate receptor function by D2-like dopamine receptors in the rat globus pallidus. 5th International mGluR meeting, Taormina, abstr 113.
Smith Y, M Kuwajima, RA Hall, P Worley and M. Dehoff (2005) Homer regulation of group I metabotropic glutamate receptors trafficking in the basal ganglia. 5th International mGluRs meeting, Taormina, abstr 137.