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Univ. of Muenster, Muenster, Germany 1980 Medicine (Preclinical)
Univ. of Freiburg, Freiburg, Germany M.D. 1984 Medicine (Clinical)
1986-88 Postdoctoral Fellow, Dept. Pharmacology, University of Freiburg, Germany
1989-90 Postdoctoral Fellow, Dept. Neurology, Johns Hopkins University, Baltimore, MD
1990-92 Assistant Professor, Dept. Neurology, Emory University, Atlanta, GA
1992-93 Intern, Dept. Medicine, Emory University, Atlanta, GA
1993-6/96 Resident, Dept. Neurology, Emory University, Atlanta, GA
1995-6/96 Chief Resident, Dept. Neurology, Emory University, Atlanta, GA
7/96-8/01 Assistant Professor, Dept. Neurology, Emory University, Atlanta, GA
10/98- Faculty, Neuroscience, Grad. Div. Biol./Biomed Sci, Emory University, Atlanta, GA
9/01- Associate Professor, Dept. Neurology, Emory University, Atlanta, GA
3/03- Faculty, Molecular/Systems Pharmacol., Grad. Div. Biol./Biomed. Sci., Emory Univ., Atlanta
1990- Member, Society for Neuroscience
1990- Member, International Basal Ganglia Society
3/00, 3/02 Visiting scientist, Tokyo Metropolitan Institute for Neuroscience
6/02- Reviewer, NIH study section (was IFCN-5, now SMI), full member since 9/03
"Basal Ganglia discharge patterns in parkinsonism"; PI: Thomas Wichmann
Agency: NINDS
Type: R01 (NS42250), period 06/15/2001-5/31/2006
These experiments aim to identify the relationshp between cortical activity and basal ganglia discharge patterns. In addition, experiments will be performed to identify the specific discharge abnormalities in the basal ganglia that underlie the development of parkinsonian motor signs.
"Influence of subthalamic nucleus on striatal dopamine"; PI: Thomas Wichmann
Agency: NINDS
Type: R01 (NS40432), period 04/01/2001-03/31/2005
These experiments aim at elucidating the complex interaction between subthalamic nucleus activity and the activity in the substantia nigra pars compacta.
"GABA-B Receptors and Parkinson‚s Disease"; Role on project: Co-investigator
Agency: NINDS
Type: R01 (NS42937) (Yoland Smith, P.I.), period: 07/01/02-06/30/06
The goal of this grant is to study the localization and functions of GABA-B receptors in the monkey basal ganglia. We also propose to test the potential therapeutic benefits of GABA-B agonists in Parkinson's disease.
"Function of dopamine in the primate substantia nigra"; PI: Thomas Wichmann
Agency: NINDS
Type: R01, period: 04/01/05-03/31/10
The experiments under this grant investigate the role of dendritic release of dopamine in the primate substantia nigra, both in normal and parkinsonian animals.
Previous
"The substantia nigra pars reticulata in movement and movement disorders"; PI: Thomas Wichmann
Agency:NINDS
Type: R01 (NS34872) Period: April 1, 1997 to March 31, 2002
The experiments in this project assessed the role of the substantia nigra pars reticulata in the control of normal movement in primates, and helped to define its role in the development of parkinsonian motor signs. The experiments also studies the effects of lesions of the substantia nigra in parkinsonian primates.
"Pathophysiology of the Basal Ganglia in Parkinsonism" (Project 4 of Parkinson's Disease Center Grant, titled, Models of Parkinson's Disease: Therapeutic implications
Project PI: Thomas Wichmann, Program Project PI: Mahlon R. DeLong
Agency: NINDS
Type: Project 4, PS0NS38399, period 10/1/1998-9/30/2003
In these experiments parkinsonism-related activity changes in glutamatergic and GABAergic neurons in the basal ganglia are explored with microdialysis, electrophysiologic and anatomical methods to better define the role of activity changes in the inidirect pathway in the development of parkinsonian motor signs.