Research Trials and Studies
Impact of Creatine, Slowing the Clinical Decline in PD Patients
Research Activities - Clinical:
- Genetic studies of movement disorders
- Trials of 'neuroprotective' drugs for movement disorders
- Trials of symptomatic drugs for movement disorders
- Trials of 'alternative' therapies for movement disorders
- Development and clinical evaluation of functional neurosurgical techniques and neurotransplantation
Research Activities - Basic:
- Functional anatomy of the basal ganglia
- Neurochemical anatomy of the basal ganglia
- Mechanisms of action of functional neurosurgical techniques
- Genetic studies of movement disorders
- Mechanisms of neurodegeneration and neuroprotection
- Environmental causes of Parkinson's disease
- Cell replacement strategies
Recent Publications:
1. Backus DA, Ye S, Russo GS, Crutcher MD (2001) Neural activity correlated with the preparation and execution of visually guided arm movements in the cingulate motor area of the monkey Preliminary findings. Exp Brain Res 140:182-189.
2. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306.
3. DeLong MR, Wichmann T (2001) Deep brain stimulation for Parkinson's disease. Ann Neurol 49:142-143.
4. Desmurget M, Grea H, Grethe JS, Prablanc C, Alexander GE, Grafton ST (2001) Functional anatomy of nonvisual feedback loops during reaching: a positron emission tomography study. J Neurosci 21:2919-2928.
5. DeStefano AL, Golbe LI, Mark MH, Lazzarini AM, Maher NE, Saint-Hilaire M, Feldman RG, Guttman M, Watts RL, Suchowersky O, Lafontaine AL, Labelle N, Lew MF, Waters CH, Growdon JH, Singer C, Currie LJ, Wooten GF, Vieregge P, Pramstaller PP, Klein C, Hubble JP, Stacy M, Montgomery E, MacDonald ME, Gusella JF, Myers RH (2001) Genome-wide scan for Parkinson's disease: the GenePD Study. Neurology 57:1124-1126.
6. Juncos JL (1999) Management of psychotic aspects of Parkinson's disease. J Clin Psychiatry 60:42-53.
7. Smith Y, Kieval JZ (2000) Anatomy of the dopamine system in the basal ganglia. Trends Neurosci 23:S28-33.
8. Stover NP, Watts RL (2001) Corticobasal degeneration. Semin Neurol 21:49-58.
9. Vitek JL, Giroux M (2000) Physiology of hypokinetic and hyperkinetic movement disorders: model for dyskinesia. Ann Neurol 47:S131-140.
10. Wichmann T, Kliem MA, DeLong MR (2001) Antiparkinsonian and behavioral effects of inactivation of the substantia nigra pars reticulata in hemiparkinsonian primates. Exp Neurol 167:410-424.