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William Tyor, MD

Professor
Department of Neurology

Neuroscience Academic Coordinator
Atlanta VA Medical Center

Phone: 404-778-3444

Fax: 404-728-4715

Biography

Dr. Tyor graduated from Emory University with a BS in Biology and then Duke University School of Medicine. He completed two years of Internal Medicine residency at Emory and his neurology residency at Baylor College of Medicine. He then completed a fellowship in neuroimmunology/neurovirology at Johns Hopkins University School of Medicine Department of Neurology. He served on the faculty at Johns Hopkins for 7 years where he participated in research and was Co-Director of the MS Clinic from 1990 to 1992. He moved to the Medical University of South Carolina in Charleston, SC. He was there for 16 years and rose to the rank of Professor. He was Director of the MUSC MS Center and Chief of Neurology at the Charleston VAMC. His research during that time was again focused on neuroimmunology and neurovirology. He moved to Emory as Professor in the Department of Neurology in 2008. He is Co-Director of the Emory/Atlanta VA MS Center and Neuroscience Academic Coordinator at the Atlanta VAMC. He continues with his research using animal models of disease and culture systems to investigate neuroimmunological and virological causes of cognitive dysfunction as well as investigating the cause and treatment of these problems in his patients. Clinics at the Atlanta VA and Emory focus on neuroinflammatory diseases of the central nervous system including multiple sclerosis and infections.

Selected Publications

Tyor WR, Glass J, Becker S, Griffin J, Bezman L, McArthur J, Griffin DE: Cytokine expression in the brain during AIDS. Ann Neurol 1992;31:349-360.

Tyor WR, Wesselingh S, Levine B, Griffin DE: Long-term intraparenchymal immunoglobulin secretion after acute viral encephalitis in mice. J Immunol 1992;149:4016-4020.

Wesselingh S, Power CC, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE: Intracerebral cytokine mRNA expression in AIDS Dementia. Ann Neurol. 1993;33:576-582.

Tyor WR, Power C, Gendelman H, Markham R: A model of HIV encephalitis in SCID mice. Proc Natl Acad Sci USA 1993. 90:8658-8662.

Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T, Tyor WR, Patil A, Nottet HSLM, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE: Human immunodeficiency virus encephalitis in SCID mice. Am J Pathol. 1996;149:1027-1053.

Shields DC, Tyor WR, Diebler GE, Banik NL. Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proc Natl Acad Sci. 1998;95:5768-5772.

Timothy Vollmer, M.D., Lyndon Key, M.D., Valerie Durkalski, Ph.D., William Tyor, M.D., John Corboy, M.D., Silva Markovic-Plese, M.D., Jana Preningerova, M.D., Marco Rizzo, M.D., Inderjit Singh, Ph.D. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet. 2004. 363: 1607-1609.

Cook J, Dasgupta S, Terry E, Gorry P, Wesselingh S, Middaugh L, and Tyor W. Highly active antiretroviral therapy of HIV-encephalitis in immunodeficient mice. Ann Neurol. 2005. 57:795-803.

Rao V, Sas A, Eugenin E, Siddappa N, Bimonte-Nelson H, Berman J, Ranga U, Tyor WR, Prasad VR. Reduced leukocyte chemotaxis and chemokine induction by a subtype C HIV isolate in vitro correlates with reduction in neuropathology and cognitive dysfunction in SCID mouse HIV encephalitis. 2008. J Neurosci. 28:10010-10016.

Sas A, Bimonte-Nelson H, Smothers CT, Woodward J, Tyor W. Interferon Alpha Causes Neuronal Dysfunction in Encephalitis. 2009. J Neurosci. 29:3948-3955.

Fritz-French C, Tyor WR. Interferon-alpha neurotoxicity. Cytokine and Growth Factor Rev. 2012. 23: 7-14.

Fritz-French C, Shawahna R, Ward JE, Maroun LE, Tyor WR. The recombinant vaccinia virus gene product, B18R, neutralizes interferon alpha and alleviates histopathological complications in an HIV encephalitis mouse model. 2014. J Interferon and Cytokine Res. 34: 510-517.

Rumbaugh JA, Tyor W. HIV associated neurocognitive disorders: Five new things. 2015. Neurology: Clinical Practice. 5: 224-231.

Haile WB, Gavegnano C, Tao S, Jiang Y, Schinazi RF, Tyor WR. The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model. 2016. Neurobiology of Disease. In press.