Seyfried Lab (Emory University)
PI: Nicholas T Seyfried
Our lab and the Seyfried labs are jointly leading projects utilizing novel in-vivo proteomic labeling strategies to define brain cell type specific proteomic signatures in mice. This critical information will inform our understanding of human brain proteomic data obtained from whole brain as well as from biofluids such as cerebrospinal fluid. We are collectively defining the first mouse endothelial proteome, and implementing a translational pipeline for biomarker discovery in which promising therapeutics are tested in mouse models and biomarker correlates of their therapeutic efficacy are being discovered in CSF and plasma. These novel biomarkers will represent potential biomarkers of efficacy and target engagement in early-phase human studies.
Wood Lab (Georgia Tech)
PI: Levi Wood
We are collectively studying the importance of ERK and JNK signaling, both MAPK pathways, in regulating neuroinflammation in AD, using in-vitro and in-vivo model systems.
Hales Lab (Emory University)
PI: Chadwick Hales
Kim Lab (Georgia Tech)
PI: Yong Tae (Tony) Kim
The Kim lab are us are developing novel nanoparticle-based formulations of Kv1.3 channel blockers with increased penetrance into the brain.
Waller Lab (Emory University)
PI: Edmund Waller
Dr Waller and his collaborator Dr Cynthia Giver are collaborating with us to use irradiation bone marrow chimerism to understand the relative contribution of peripheral myeloid cells and microglia to the neurodegenerative disease process.
Thinakaran Lab (Morsani College of Medicine, Tampa FL)
PI: Gopal Thinakaran
The focus of this ongoing collaboration is to define the role of the AD risk gene Bin1 as a regulator of microglia-mediated neuroinflammation.