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Selected Publications

Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, Reiman EM, Haroutunian V, Wang M, Schadt E, Zhang B, Dickson DW, -Taner N, Golde TE, Petyuk VA, De Jager PL, Bennett DA, Wingo TS, Rangaraju S, Hajjar I, Shulman JM, Lah JJ, Levey AI, Seyfried NT. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nat Med. 2020 Apr 13. doi: 10.1038/s41591-020-0815-6. Epub ahead of print. PMID: 32284590.

Sarkar S, Dammer EB, Malovic E, Olsen AL, Raza SA, Gao T, Xiao H, Oliver DL, Duong D, Joers V, Seyfried N, Huang M, Kukar T, Tansey MG, Kanthasamy AG, Rangaraju S. Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells. Front Immunol. 2020 Jan 31;11:33. doi: 10.3389/fimmu.2020.00033. PMID: 32082315; PMCID: PMC7006296.

Gao T, Jernigan J, Raza SA, Dammer EB, Xiao H, Seyfried NT, Levey AI, Rangaraju S. Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα. Glia. 2019 Oct;67(10):1958-1975. doi: 10.1002/glia.23678. Epub 2019 Jul 13. PubMed PMID: 31301160.

Gao T, Raza SA, Ramesha S, Nwabueze NV, Tomkins AJ, Cheng L, Xiao H, Yepes M, Rangaraju S. Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke. J Neuroinflammation. 2019 Jun 1;16(1):116. doi: 10.1186/s12974-019-1510-8. PubMed PMID: 31153377; PubMed Central PMCID: PMC6545199.

Rangaraju S, Dammer EB, Raza SA, Gao T, Xiao H, Betarbet R, Duong DM, Webster JA, Hales CM, Lah JJ, Levey AI, Seyfried NT. Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins. Mol Neurodegener. 2018 Jun 28;13(1):34. doi: 10.1186/s13024-018-0266-4. PubMed PMID: 29954413; PubMed Central PMCID: PMC6025801.

Rangaraju S, Dammer EB, Raza SA, Rathakrishnan P, Xiao H, Gao T, Duong DM, Pennington MW, Lah JJ, Seyfried NT, Levey AI. Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease. Mol Neurodegener. 2018 May 21;13(1):24. doi: 10.1186/s13024-018-0254-8. PubMed PMID: 29784049.

Rangaraju S, Raza SA, Li NX, Betarbet R, Dammer EB, Duong D, Lah JJ, Seyfried NT, Levey AI. Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes-Activation and Age-Related Effects. Front Immunol. 2018 Mar 2;9:405. doi: 10.3389/fimmu.2018.00405. eCollection 2018. PubMed PMID: 29552013; PubMed Central PMCID: PMC5840283.

Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain. 2018 Feb 1;141(2):596-612. doi: 10.1093/brain/awx346. PubMed PMID: 29272333; PubMed Central PMCID: PMC5837198.

Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation. J Neuroinflammation. 2017 Jun 26;14(1):128. doi: 10.1186/s12974-017-0906-6. PubMed PMID: 28651603; PubMed Central PMCID: PMC5485721.

Pennati A, Ng S, Wu Y, Murphy JR, Deng J, Rangaraju S, Asress S, Blanchfield JL, Evavold B, Galipeau J. Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation. J Neurosci. 2016 Dec 14;36(50):12598-12610. Epub 2016 Nov 7. PubMed PMID: 27821578; PubMed Central PMCID: PMC5157105.

Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 2016 Mar 24;318:22-33. doi: 10.1016/j.neuroscience.2016.01.008. Epub 2016 Jan 12. PubMed PMID: 26791526; PubMed Central PMCID: PMC4753827.

Rangaraju S, Gearing M, Jin LW, Levey A. Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. J Alzheimers Dis. 2015;44(3):797-808. doi: 10.3233/JAD-141704. PubMed PMID: 25362031; PubMed Central PMCID: PMC4402159. 

Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010 Mar 19;285(12):9124-36. doi: 10.1074/jbc.M109.071266. Epub 2009 Dec 4. PubMed PMID: 19965868; PubMed Central PMCID: PMC2838332.

Rangaraju S, Chi V, Pennington MW, Chandy KG. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009 Aug;13(8):909-24. doi: 10.1517/14728220903018957. Review. PubMed PMID: 19538097.

Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr;75(4):762-73. doi: 10.1124/mol.108.052704. Epub 2009 Jan 2. PubMed PMID: 19122005; PubMed Central PMCID: PMC2684922.

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker  I, Chandy KG, Cahalan MD. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29(4):602-14. doi:  10.1016/j.immuni.2008.07.015. Epub 2008 Oct 2. PubMed PMID: 18835197; PubMed Central PMCID: PMC2732399.

A complete publication list for Dr Rangaraju can be found at: https://www.ncbi.nlm.nih.gov/sites/myncbi/srikant.rangaraju.1/bibliography/42779717/public/?sort=date&direction=descending