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Selected Publications

Rangaraju S, Raza SA, Pennati A, Deng Q, Dammer EB, Duong D, Pennington MW, Tansey MG, Lah JJ, Betarbet R, Seyfried NT, Levey AI. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation. J Neuroinflammation. 2017 Jun 26;14(1):128. doi: 10.1186/s12974-017-0906-6. PubMed PMID: 28651603; PubMed Central PMCID: PMC5485721.

Pennati A, Ng S, Wu Y, Murphy JR, Deng J, Rangaraju S, Asress S, Blanchfield JL, Evavold B, Galipeau J. Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation. J Neurosci. 2016 Dec 14;36(50):12598-12610. Epub 2016 Nov 7. PubMed PMID: 27821578; PubMed Central PMCID: PMC5157105.

Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 2016 Mar 24;318:22-33. doi: 10.1016/j.neuroscience.2016.01.008. Epub 2016 Jan 12. PubMed PMID: 26791526; PubMed Central PMCID: PMC4753827.

Rangaraju S, Gearing M, Jin LW, Levey A. Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. J Alzheimers Dis. 2015;44(3):797-808. doi: 10.3233/JAD-141704. PubMed PMID: 25362031; PubMed Central PMCID: PMC4402159. 

Rangaraju S, Khoo KK, Feng ZP, Crossley G, Nugent D, Khaytin I, Chi V, Pham C, Calabresi P, Pennington MW, Norton RS, Chandy KG. Potassium channel modulation by a toxin domain in matrix metalloprotease 23. J Biol Chem. 2010 Mar 19;285(12):9124-36. doi: 10.1074/jbc.M109.071266. Epub 2009 Dec 4. PubMed PMID: 19965868; PubMed Central PMCID: PMC2838332.

Rangaraju S, Chi V, Pennington MW, Chandy KG. Kv1.3 potassium channels as a therapeutic target in multiple sclerosis. Expert Opin Ther Targets. 2009 Aug;13(8):909-24. doi: 10.1517/14728220903018957. Review. PubMed PMID: 19538097.

Pennington MW, Beeton C, Galea CA, Smith BJ, Chi V, Monaghan KP, Garcia A, Rangaraju S, Giuffrida A, Plank D, Crossley G, Nugent D, Khaytin I, Lefievre Y, Peshenko I, Dixon C, Chauhan S, Orzel A, Inoue T, Hu X, Moore RV, Norton RS, Chandy KG. Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes. Mol Pharmacol. 2009 Apr;75(4):762-73. doi: 10.1124/mol.108.052704. Epub 2009 Jan 2. PubMed PMID: 19122005; PubMed Central PMCID: PMC2684922.

Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker  I, Chandy KG, Cahalan MD. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29(4):602-14. doi:  10.1016/j.immuni.2008.07.015. Epub 2008 Oct 2. PubMed PMID: 18835197; PubMed Central PMCID: PMC2732399.

A complete publication list for Dr Rangaraju can be found at: https://www.ncbi.nlm.nih.gov/sites/myncbi/srikant.rangaraju.1/bibliography/42779717/public/?sort=date&direction=descending