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Welcome to the Wharton Laboratory Website!

We are tremendously grateful to our research participants and our community volunteers for making our research a possibility.

Our Mission:


Our laboratory investigates in the influence of midlife vascular risk factors on Alzheimer's Disease we develop observational & clinical trials in hopes of reducing Alzheimer's Disease in people most at risk, including individuals with a parental history of Alzheimer's Disease and African Americans.

Areas of investigation include:
  • Understanding the contribution of midlife vascular risk factors in Alzheimer's Disease and developing vascular interventions to target the most relevant Alzheimer's Disease biomarkers including beta amyloid accumulation and cerebral hypoperfusion in individuals at high risk for Alzheimer's Disease
  • Testing whether certain blood pressure medications penetrate the brain and act on Alzheimer's Disease biomarkers, thereby potentially reducing Alzheimer's Disease risk.
  • Testing potential racial differences in the way that blood pressure medications penetrate the brain and potentially influence Alzheimer's Disease risk.

Click here to view Dr. Wharton's CV.

Click here to visit the ADRC Facebook page

Click here to watch study participants discussing their lumbar punctures and here to read some FAQs about lumbar punctures.