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Yepes Laboratory Recent Publications

Some of our more relevant publications from the last years are listed below.  For a complete list of publications visit:


Yepes, M.  TWEAK and Fn14 in the Neurovascular UnitFrontiers in Immunology. 2013. In Press.

An J, Haile WB, Wu F, Torre E, Yepes M. Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system. Neuroscience. 2013 Nov 4. doi:pii: S0306-4522(13)00913-5. 10.1016/j.

Wu F, Nicholson AD, Haile WB, Torre E, An J, Chen C, Lee AK, Duong DM, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Yepes M. Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress. J Cereb Blood Flow Metab. 2013 Nov;33(11):1761-9.

Wu F, Echeverry R, Wu J, An J, Haile WB, Cooper DS, Catano M, Yepes M.  Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK ½-CREB-ATF3 signaling pathway. Mol Cell Neurosci. 2013 Jan;52:9-19.


Wu F., Wu, J., Nicholson A., Echeverry R., Haile WB., Catano M., An J., Lee AK., Duong D., Dammer EB., Seyfried NT., Tong FC., Votaw JR., Medcalf RL., Yepes M.  Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain  Journal of Neurosciences.  Jul 18;32(29):9848-9858.

Haile WB, Wu, J, Echeverry R, Wu F, An J, Wu F, Yepes M.  Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α.  Journal of Cerebral Blood Flow & Metabolism. 2012 Jan;32(1):57-69.

Echeverry R., Wu F., Wu J., Haile W., Yepes M.  TWEAK has a protective effect in the ischemic brain.  Journal of Neuroinflammation. 2012 Mar 6;9:45.


Chan CB, Liu X., Pradoldej S., Hao C., An J., Yepes M., Luo HR and Ye J.  PIKE Regulates Neuronal Dendritogenesis and Survival in Neocortex.  Journal of Neurosciences. Jun 1;31(22):8083-92.


Haile WB, Echeverry R, Wu J, Yepes M. The interaction between tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-   inducible 14 promotes the recruitment of neutrophils into the ischemic brain Journal of Cerebral Blood Flow & Metabolism  2010 Jun;30(6):1147-56

Echeverry R., Wu, Jialing, Guzman J., Haile W, Yepes M.  tPA is an endogenousneuroprotectant in the murine hippocampus.  Journal of Clinical Investigation. 2010. Jun 1;120(6):2194-205.

Wu, J., Guzman, J., Haile W., Yepes M.  Neuroserpin inhibits plasmin-induced cell death via a tPA-independent mechanism.  American Journal of Pathology. 2010.Sep 23.


Zhang CH., An J., Strickland DK., Yepes M.  The Low Density Lipoprotein receptor related Protein 1 (LRP1) mediates tPA-induced microglial activation in the ischemic brain.  American Journal of Pathology. 2009 Feb; 174 (2) 586-594.

Zhang CH., An J. Haile BW, Echeverry R., Strickland DK., Yepes M.  Microglial Low Density Liporprotein Receptor-related Protein 1 (LRP1) Mediates the effect of Tissue-type Plasminogen Activator on MMP-9 activity in the ischemic Brain.  Journal of Cerebral Blood Flow & Metabolism 2009 Dec;29(12):1946-54.

Yepes M, Vivien D.  Tissue-Type Plasminogen Activator in the Ischemic Brain.  Trends In Neurosciences. 2009 32(1); 48-55.


Polavarapu R., An Jie, Zhang CH, Yepes, M. LRP-mediated ischemic cell death.  Am J Pathol. 2008 May;172(5):1355-62.

An Jie, Zhang CH, Polavarapu R, Zhang X, Yepes, M. TPA and the Low density Lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood; 2008 Oct 1;112(7):2787-94.


Zhang X., Winkles J., Gongora MC., Polavarapu R., Michaelson JS., Hahm K., Burkly L., Friedman M., Li XJ., Yepes M. TWEAK-Fn14 Pathway Inhibition Protects the Integrity of the Neurovascular Unit During Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism. 2007. 1-11.

Polavarapu R, Gongora MC, Yi H, Ranganthan S, Lawrence DA, Strickland D, Yepes M. Tissue-type plasminogen activator-mediated shedding of astrocytic low density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood. 2007 April 15;109(8):3270-8.

Zhang X, Polavarapu R., She H., Mao X, Yepes M. Tissue-type Plasminogen Activator and the Low density lipoprotein receptor-related protein mediate NF-κB pathway activation during cerebral ischemia. The American Journal of Pathology. 2007. Oct;171(4):1281-90.

Yepes M. TWEAK and Fn14 in Central Nervous System Health and Disease. Frontiers in Bioscience. 2007. May 1. 2177-2185 2007