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Yepes Laboratory Recent Publications

Some of our more relevant publications from the last years are listed below.  For a complete list of publications visit: http://www.ncbi.nlm.nih.gov/pubmed?term=Yepes%20M

2013

Yepes, M.  TWEAK and Fn14 in the Neurovascular UnitFrontiers in Immunology. 2013. In Press.

An J, Haile WB, Wu F, Torre E, Yepes M. Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system. Neuroscience. 2013 Nov 4. doi:pii: S0306-4522(13)00913-5. 10.1016/j.

Wu F, Nicholson AD, Haile WB, Torre E, An J, Chen C, Lee AK, Duong DM, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Yepes M. Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress. J Cereb Blood Flow Metab. 2013 Nov;33(11):1761-9.

Wu F, Echeverry R, Wu J, An J, Haile WB, Cooper DS, Catano M, Yepes M.  Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK ½-CREB-ATF3 signaling pathway. Mol Cell Neurosci. 2013 Jan;52:9-19.

2012

Wu F., Wu, J., Nicholson A., Echeverry R., Haile WB., Catano M., An J., Lee AK., Duong D., Dammer EB., Seyfried NT., Tong FC., Votaw JR., Medcalf RL., Yepes M.  Tissue-Type Plasminogen Activator Regulates the Neuronal Uptake of Glucose in the Ischemic Brain  Journal of Neurosciences.  Jul 18;32(29):9848-9858.

Haile WB, Wu, J, Echeverry R, Wu F, An J, Wu F, Yepes M.  Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α.  Journal of Cerebral Blood Flow & Metabolism. 2012 Jan;32(1):57-69.

Echeverry R., Wu F., Wu J., Haile W., Yepes M.  TWEAK has a protective effect in the ischemic brain.  Journal of Neuroinflammation. 2012 Mar 6;9:45.

2011 

Chan CB, Liu X., Pradoldej S., Hao C., An J., Yepes M., Luo HR and Ye J.  PIKE Regulates Neuronal Dendritogenesis and Survival in Neocortex.  Journal of Neurosciences. Jun 1;31(22):8083-92.

2010 

Haile WB, Echeverry R, Wu J, Yepes M. The interaction between tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-   inducible 14 promotes the recruitment of neutrophils into the ischemic brain Journal of Cerebral Blood Flow & Metabolism  2010 Jun;30(6):1147-56

Echeverry R., Wu, Jialing, Guzman J., Haile W, Yepes M.  tPA is an endogenousneuroprotectant in the murine hippocampus.  Journal of Clinical Investigation. 2010. Jun 1;120(6):2194-205.

Wu, J., Guzman, J., Haile W., Yepes M.  Neuroserpin inhibits plasmin-induced cell death via a tPA-independent mechanism.  American Journal of Pathology. 2010.Sep 23.

2009 

Zhang CH., An J., Strickland DK., Yepes M.  The Low Density Lipoprotein receptor related Protein 1 (LRP1) mediates tPA-induced microglial activation in the ischemic brain.  American Journal of Pathology. 2009 Feb; 174 (2) 586-594.

Zhang CH., An J. Haile BW, Echeverry R., Strickland DK., Yepes M.  Microglial Low Density Liporprotein Receptor-related Protein 1 (LRP1) Mediates the effect of Tissue-type Plasminogen Activator on MMP-9 activity in the ischemic Brain.  Journal of Cerebral Blood Flow & Metabolism 2009 Dec;29(12):1946-54.

Yepes M, Vivien D.  Tissue-Type Plasminogen Activator in the Ischemic Brain.  Trends In Neurosciences. 2009 32(1); 48-55.

2008 

Polavarapu R., An Jie, Zhang CH, Yepes, M. LRP-mediated ischemic cell death.  Am J Pathol. 2008 May;172(5):1355-62.

An Jie, Zhang CH, Polavarapu R, Zhang X, Yepes, M. TPA and the Low density Lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood; 2008 Oct 1;112(7):2787-94.

2007

Zhang X., Winkles J., Gongora MC., Polavarapu R., Michaelson JS., Hahm K., Burkly L., Friedman M., Li XJ., Yepes M. TWEAK-Fn14 Pathway Inhibition Protects the Integrity of the Neurovascular Unit During Cerebral Ischemia. Journal of Cerebral Blood Flow & Metabolism. 2007. 1-11.

Polavarapu R, Gongora MC, Yi H, Ranganthan S, Lawrence DA, Strickland D, Yepes M. Tissue-type plasminogen activator-mediated shedding of astrocytic low density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood. 2007 April 15;109(8):3270-8.

Zhang X, Polavarapu R., She H., Mao X, Yepes M. Tissue-type Plasminogen Activator and the Low density lipoprotein receptor-related protein mediate NF-κB pathway activation during cerebral ischemia. The American Journal of Pathology. 2007. Oct;171(4):1281-90.

Yepes M. TWEAK and Fn14 in Central Nervous System Health and Disease. Frontiers in Bioscience. 2007. May 1. 2177-2185 2007